Thursday, 16 August 2012

Symptoms of Mesothelioma

Symptoms of Mesothelioma

Patients with mesothelioma generally do not demonstrate symptoms of this disease until 20 to 50 years after their initial exposure to asbestos. Fibers that embed in the tissue surrounding the body’s internal organs, the mesothelium, usually must be present for many decades before the development of cancer. These fibers gradually accumulate and cause scarring, which leads to inflammation and cancer. Although these fibers are most often introduced into the body through inhalation, the material can also be introduced through ingestion as well. Initially, symptoms may be mild and an individual might not find them cause for alarm. However, as the cancer spreads, these symptoms become more severe and debilitating.   
Consulting a Physician Earlydoctor with patient

As a result of this slow development and long delay between asbestos exposure and cancer growth, individuals frequently overlook initial symptoms of mesothelioma. Furthermore, these symptoms often mimic those of less serious illnesses, leading to a common delay in seeking treatment. Unfortunately, this delay can limit treatment options and effectiveness. Therefore, it remains vital for any individuals who suspect past asbestos exposure to seek medical screening for the disease, even if symptoms are not currently present. Oftentimes, a second opinion is also recommended as mesothelioma is commonly misdiagnosed. Whether it is the stage the cancer is in, or the type of cancer, misdiagnosis happens and specialists advise patients to get second opinions. Diagnosis of mesothelioma as a stage III when it really is a stage II is a big difference and treatment options as well as prognosis may differ greatly between stages.

Several important steps after diagnosis exist for patients struggling with mesothelioma. These steps can be the difference between succumbing to the disease quickly and maintaining a high quality of life while fighting this illness. Even if symptoms that seem trivial arise, it is important to contact a physician immediately. This is especially vital for those who have had exposure to asbestos in the past.
Early Symptoms Stages of Mesothelioma
Early symptoms of mesothelioma are generally absent in patients, leading to the disease’s late diagnosis. However, it remains vital for those who were exposed to asbestos to seek regular imaging and diagnostic tests to help detect any latent signs of mesothelioma development. Individuals who experienced prolonged asbestos contact should be even more attentive to this risk, as length and intensity of exposure is strongly correlated with the development of mesothelioma.

Sometimes early symptoms of mesothelioma mirror those of other diseases or physical issues such as congestive heart failure, emphysema, weight gain or constipation. These symptoms may include shortness of breath, constant chest pain or cough, night sweats, weight loss but fluid gain, bowel obstruction, swelling of the feet, and a buildup of fluid on a chest x-ray. This fluid build up is known as a pleural effusion.
What is a Pleural Effusion?

Pleral Fluid Chart

One main symptom of mesothelioma is a buildup of the fluid between the parietal pleura and the visceral pleura. This buildup is called a pleural effusion. These membranes are coated with mesothelial cells that normally secrete a fluid that lubricates and protects the space between one’s chest wall and lung. In a healthy body, excess fluid would be absorbed into the bloodstream and lymph nodes to avoid fluid buildup. Conversely, for abnormal cases such as those seen in mesothelioma, when too much fluid is present in the area, a pleural effusion occurs.

There are two types of pleural effusions. The most common form is a transudative pleural effusion. This effusion is typically clear in color and occurs when there is an imbalance between fluid produced and that which is removed. This form is more common in a congestive heart failure.

An exudative effusion is likely to be a sign of mesothelioma. This effusion is cloudy in color and made up of cells, proteins and other fluids resembling that of a diseased pleura. In order to differentiate between the two types of effusions a fluid sample must be tested.

Removal of excess fluid can be done in a simple procedure requiring local anesthesia. The procedure, called pleurodesis, injects talc into the fluid in the lungs. According to the American Cancer Society, this substance causes irritation in the membranes making them swell and stick together. Once this bond is formed, space is eliminated making the area impermeable to fluid. 

Another procedure, called pleurocentesis is a simple outpatient procedure typically lasting only 30 minutes. During this procedure, a long needle is injected through the chest cavity into the lung and drains excess fluid from the lungs.
Pleural Mesothelioma Symptoms

The most common form of this disease, pleural mesothelioma, makes up approximately 75% of all mesothelioma cases. Developing in the pulmonary (lung) region, symptoms of this disease include:

    Persistent dry cough without phlegm
    Plueral effusions (typically containing blood)
    Blood in the sputum (fluid) or coughing up blood (hemoptysis)
    Difficulty swallowing (dysphagia)
    Inexplicable weight loss
    Fatigue
    Sweating or fever
    Persistent chest or rib area pain, painful breathing
    Inexplicable shortness of breath (dyspnea)
    Development of lumps under the skin on the chest

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